abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates hematopoiesis, inflammation, immune responses and bone homeostasis in mammals. Fish IL-6 has been cloned in recent years but to date no functional studies have been reported. Thus, in this paper we present for the first time in fish the functional character...

journal_title：Molecular immunology

authors： Costa MM,Maehr T,Diaz-Rosales P,Secombes CJ,Wang T

更新日期：2011-09-01 00:00:00

abstract：:Trichosanthin (TCS) is a type I ribosome-inactivating protein with wide spectrum of pharmacological activities. It inhibits human immunodeficiency virus type 1 (HIV-1) and Herpes simplex virus type 1 (HSV-1) replication but the mechanism is not clear. From a previous study, TCS was found to be more cytotoxic to HIV-1 ...

journal_title：Molecular immunology

authors： He D,Yau K,He X,Shi H,Zheng Y,Tam S

更新日期：2011-09-01 00:00:00

abstract：:Porphyromonas gingivalis causes periodontal diseases and its lipopolysaccharide (LPS) is considered as a major virulence factor responsible for pathogenesis. Since initial recognition of P. gingivalis LPS (Pg.LPS) in the oral cavity might be crucial for the host response, we identified Pg.LPS-binding proteins (Pg.LPS-...

journal_title：Molecular immunology

authors： Choi S,Baik JE,Jeon JH,Cho K,Seo DG,Kum KY,Yun CH,Han SH

更新日期：2011-09-01 00:00:00

abstract：:Polymorphonuclear cells (PMN) are widely recognized as sophisticated killers during microbial infections. In recent years, PMN have been shown to interact and functionally interfere with other cells of the immune system. In this study, we investigated PMN-T cell interactions in an in vitro co-culture system. A relativ...

journal_title：Molecular immunology

authors： Thewissen M,Damoiseaux J,van de Gaar J,Tervaert JW

更新日期：2011-09-01 00:00:00

abstract：:Candida albicans is an opportunistic human-pathogenic fungus, which can cause superficial but also life-threatening invasive infections. The pH-regulated antigen 1 (Pra1) of C. albicans is a surface-associated and secreted protein highly expressed in the hyphal form. Pra1 can bind to complement receptor 3 (CD11b/CD18)...

journal_title：Molecular immunology

authors： Losse J,Svobodová E,Heyken A,Hube B,Zipfel PF,Józsi M

更新日期：2011-09-01 00:00:00

abstract：:Inhibition of C5a by antibodies has been demonstrated to dramatically improve survival in various sepsis models in mice and rats. The structural basis of C5a mediated bioactivity and C5a antibody mediated neutralization are of interesting to be investigated. In the previous study, we obtained a novel functional mouse ...

journal_title：Molecular immunology

authors： Wei H,Lin Z,Feng J,Peng H,Guo R,Han G,Geng S,Lang X,Sun Y,Shen B,Li Y

更新日期：2011-07-01 00:00:00

abstract：:Cytohesin-1 is a guanine nucleotide exchange factor for ADP ribosylation factor 6 (Arf6) in human blood neutrophils and differentiated PLB-985 neutrophil-like cells. Cytohesin-1 regulates adhesion and the transendothelial migration of monocytes, dendritic cells and T lymphocytes through activation of the β2 integrin L...

journal_title：Molecular immunology

authors： El azreq MA,Bourgoin SG

更新日期：2011-07-01 00:00:00

abstract：:The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be extrapolated to the corresponding scenario in hum...

journal_title：Molecular immunology

authors： Talavera A,Mackenzie J,Garrido G,Friemann R,López-Requena A,Moreno E,Krengel U

更新日期：2011-07-01 00:00:00

abstract：:Interleukin 1β (IL-1β) is a pro-inflammatory cytokine secreted by activated macrophages and monocytes. Previously, we have reported that bone morphogenetic protein-6 (BMP-6) induces inducible nitric oxide synthase (iNOS) expression via IL-1β in macrophages. In the present study, we demonstrate that BMP-6 increases IL-...

journal_title：Molecular immunology

authors： Lee GT,Jung YS,Lee JH,Kim WJ,Kim IY

更新日期：2011-07-01 00:00:00

abstract：:Induction of the TCR signaling pathway terminates the expression of RAG genes, and a link between this pathway and their transcriptional control is evident from the recent demonstration of their re-expression if the TCR is subsequently lost or down-regulated. Since unstimulated T cells display a steady-state level of ...

journal_title：Molecular immunology

authors： Orlando L,Accomasso L,Circosta P,Turinetto V,Lantelme E,Porcedda P,Minieri V,Pautasso M,Willemsen RA,Cignetti A,Giachino C

更新日期：2011-07-01 00:00:00

abstract：:Although the etiology of rheumatoid arthritis (RA) remains unknown, it has been widely suggested that RA has a genetic background. In humans, a copy number loss of 22q11.2, a region harboring the VPREB1 gene, has been suggested to be associated with several immunologic disorders, but there has been no study on the cop...

journal_title：Molecular immunology

authors： Yim SH,Chung YJ,Jin EH,Shim SC,Kim JY,Kim YS,Hu HJ,Shin SH,Pae HO,Zouali M,Chung HT

更新日期：2011-06-01 00:00:00

abstract：:Proteolytic processing of transmembrane receptors and ligands can have a dramatic impact on cell signaling processes and subsequent cellular responses, including activation and differentiation. A member of the disintegrin and metalloproteinase family, ADAM10, has emerged as a prominent regulator of numerous receptors ...

journal_title：Molecular immunology

authors： Gibb DR,Saleem SJ,Chaimowitz NS,Mathews J,Conrad DH

更新日期：2011-06-01 00:00:00

abstract：:A complex interplay between the microbiota and the host immune system is evidenced to shape the immune system throughout life, but little is known about the microbial effect on key players of the adaptive immune system, the B2 B cells. In the presented study, we have evaluated the effect of commensal bacteria on B cel...

journal_title：Molecular immunology

authors： Hansson J,Bosco N,Favre L,Raymond F,Oliveira M,Metairon S,Mansourian R,Blum S,Kussmann M,Benyacoub J

更新日期：2011-05-01 00:00:00

abstract：:White spot syndrome virus (WSSV) has caused great economic damage to shrimp aquaculture. Previous studies have shown that WSSV successfully usurps the immunity system of the host for its own gene regulation. To investigate the role of shrimp high mobility group box (HMGB) proteins in WSSV gene regulation, two Litopena...

journal_title：Molecular immunology

authors： Chen YH,Jia XT,Huang XD,Zhang S,Li M,Xie JF,Weng SP,He JG

更新日期：2011-02-01 00:00:00

abstract：:SOCS3 is well known to negatively regulate various cytokine-mediated signaling responses, but its direct role in the expression of specific cytokines has not been clearly elucidated. To understand the role of SOCS3 in the expression of IL-4, one of the key Th2 cytokines, RBL-2H3 cells (a rat mast cell line) were engin...

journal_title：Molecular immunology

authors： Kim D,Kim SH,Cho SH,Shin K,Kim S

更新日期：2011-02-01 00:00:00

abstract：:SHP-1 plays an important role for the regulation of signaling from various hematopoietic cell receptors. In this study, we examined IL-3-induced cell proliferation and IL-3 depletion-induced apoptosis in bone marrow-derived mast cells (BMMC) established from motheaten (me) that lack SHP-1 expression, viable motheaten ...

journal_title：Molecular immunology

authors： Nakata K,Suzuki Y,Inoue T,Ra C,Yakura H,Mizuno K

更新日期：2011-01-01 00:00:00

abstract：:By binding to T cell Ig mucin-3 (Tim-3) expressed on different cells, galectin-9 (Gal-9) mediates two important functions, triggering T cell death and activating innate immune cells. The mechanisms by which ligation of the same molecule on different cell types mediates different effects are largely unclear. Gal-9 cont...

journal_title：Molecular immunology

authors： Li Y,Feng J,Geng S,Geng S,Wei H,Chen G,Li X,Wang L,Wang R,Peng H,Han G,Shen B,Li Y

更新日期：2011-01-01 00:00:00

abstract：:MHC class I molecules present short peptides, usually 8-10 amino acids in length, to CD8(+) T cells. These peptides are typically generated from full-length endogenously synthesized proteins degraded by the antigen processing machinery of the target cell. However, exogenous proteins, whether originating from intracell...

journal_title：Molecular immunology

authors： Wolf BJ,Princiotta MF

更新日期：2011-01-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a recognition molecule of the complement (C) system and binds to carbohydrate ligands present on a wide range of pathogenic bacteria, viruses, fungi, and parasites. MBL has been detected in the cervico-vaginal cavity where it can provide a first-line defence against infectious agents co...

journal_title：Molecular immunology

authors： Bulla R,De Seta F,Radillo O,Agostinis C,Durigutto P,Pellis V,De Santo D,Crovella S,Tedesco F

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Nuclear components targeted by autoantibodies are a characteristic feature of the autoimmune disease systemic lupus erythematosus (SLE). The nucleosome, a major autoantigen, is released in patients with SLE as a result of a disturbed apoptosis and/or an insufficient clearance of apoptotic debris. During apopt...

journal_title：Molecular immunology

authors： van Bavel CC,Dieker JW,Tamboer WP,van der Vlag J,Berden JH

更新日期：2010-11-01 00:00:00

abstract：:Previous work from our laboratories has demonstrated that purified, recombinant human astrovirus coat protein (HAstV CP) binds C1q and mannose-binding lectin (MBL) inhibiting activation of the classical and lectin pathways of complement, respectively. Analysis of the 787 amino acid CP molecule revealed that residues 7...

journal_title：Molecular immunology

authors： Gronemus JQ,Hair PS,Crawford KB,Nyalwidhe JO,Cunnion KM,Krishna NK

更新日期：2010-11-01 00:00:00

abstract：:It is well established that many cell functions are controlled by the PI-3K signaling pathway and the signaling lipid, phosphatidylinositol-3,4,5-triphosphate (PIP3). This is particularly true for mast cells which play a key regulatory role in allergy and inflammation through activation via high-affinity IgE receptors...

journal_title：Molecular immunology

authors： Shenker BJ,Boesze-Battaglia K,Zekavat A,Walker L,Besack D,Ali H

更新日期：2010-11-01 00:00:00

abstract：:Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways. In spite of the important potential functions attributed to Zac1, little is known of its physiological regulation and biological function. We dis...

journal_title：Molecular immunology

authors： Warzée B,Mesnil C,Hober D,Caloone D,Pirottin D,Garigliany MM,Desmecht D,Drion PV,Journot L,Lekeux P,Bureau F,Desmet CJ

更新日期：2010-11-01 00:00:00

abstract：:IL-10 plays a critical role in controlling inflammation and the anti-inflammatory functions of IL-10 are regulated based on its coordinated expression from various cellular sources, most notably T cells. Although nearly all CD4+ subpopulations can express IL-10, surprisingly little is known about the molecular mechani...

journal_title：Molecular immunology

authors： Hedrich CM,Ramakrishnan A,Dabitao D,Wang F,Ranatunga D,Bream JH

更新日期：2010-11-01 00:00:00

abstract：:The generation of T cell receptor (TCR) sequence diversity can produce 'forbidden' clones able to recognize self-antigens. Here, the structure of the complex between a myelin basic protein peptide (MBP85-99), human leukocyte antigen (HLA)-DR2 (DRB1*1501/DRA) and TCR-Ob.2F3, the dominant autoimmune clone obtained from ...

journal_title：Molecular immunology

authors： Kato Z,Stern JN,Nakamura HK,Miyashita N,Kuwata K,Kondo N,Strominger JL

更新日期：2010-11-01 00:00:00

abstract：:TRAF6 is a key player at the cross-roads of development and immunity. The analysis of its in vivo molecular function is a great challenge since severe developmental defects and early lethality caused by Traf6 deficiency in knock-out mice interfere with analyses of the immune response. In this study we have used a new ...

journal_title：Molecular immunology

authors： Stockhammer OW,Rauwerda H,Wittink FR,Breit TM,Meijer AH,Spaink HP

更新日期：2010-11-01 00:00:00

abstract：:The high affinity receptor for IgE (FcvarepsilonRI) is constitutivelly expressed on the surface of mast cells and basophils as a multimeric complex. Upon antigen ligation to FcvarepsilonRI-bound IgE molecules, the receptor complex transduces intracellular signals leading to the release of preformed and newly synthesis...

journal_title：Molecular immunology

authors： Molfetta R,Gasparrini F,Santoni A,Paolini R

更新日期：2010-09-01 00:00:00

abstract：:Triptolide is an active component of extracts derived from the medicinal vine Tripterygium Wilfordii Hook. f. (TWHF) whose extracts have been used to treat inflammatory bowel disease (IBD). We have reported that triptolide showed therapeutic activity in a murine IBD model, but the potential mechanism of action of this...

journal_title：Molecular immunology

authors： Li Y,Yu C,Zhu WM,Xie Y,Qi X,Li N,Li JS

更新日期：2010-09-01 00:00:00

abstract：:The complement system is an essential component of the innate immune system that participates in elimination of pathogens and altered host cells and comprises an essential link between the innate and adaptive immune system. Soluble and membrane-bound complement regulators protect cells and tissues from unintended comp...

journal_title：Molecular immunology

authors： Ferreira VP,Pangburn MK,Cortés C

更新日期：2010-08-01 00:00:00

abstract：:Some IgM cattle antibodies are amongst the largest known to exist in jawed vertebrates where CDR3H size may extend up to 61 amino acids. To understand the origin of such an exceptionally long CDR3H, bovine D(H) gene locus was completely characterized from Holstein cattle that revealed the presence of a total of eight ...

journal_title：Molecular immunology

authors： Koti M,Kataeva G,Kaushik AK

更新日期：2010-07-01 00:00:00

abstract：:Dendritic cells (DCs) are the professional antigen-presenting cells (APC) which efficiently prime the immune response or induce tolerance. We recently identified Dendritic Cell Specific TrAnsMembrane Protein (DC-STAMP), a novel 470 amino acid protein preferentially expressed by dendritic cells. Previously we demonstra...

journal_title：Molecular immunology

authors： Eleveld-Trancikova D,Sanecka A,van Hout-Kuijer MA,Looman MW,Hendriks IA,Jansen BJ,Adema GJ

更新日期：2010-07-01 00:00:00

abstract：:Pulmonary surfactant proteins, SP-A and SP-D, are carbohydrate pattern recognition molecules of innate immunity, which significantly enhance phagocytosis and killing of Aspergillus fumigatus, a pathogenic fungus, by neutrophils and macrophages. The present study examined the susceptibility of immunosuppressed SP-A gen...

journal_title：Molecular immunology

authors： Madan T,Reid KB,Clark H,Singh M,Nayak A,Sarma PU,Hawgood S,Kishore U

更新日期：2010-06-01 00:00:00

abstract：:Conserved extended haplotypes (CEHs) are large (>or=1Mb) regions of identical DNA of the major histocompatibility complex (MHC) region of chromosome 6p in unrelated individuals. They are recognized by family studies and constitute nearly half of MHC haplotypes among European Caucasians. We studied 49 Hungarian Caucasi...

journal_title：Molecular immunology

authors： Szilágyi A,Bánlaki Z,Pozsonyi E,Yunis EJ,Awdeh ZL,Hossó A,Rajczy K,Larsen CE,Fici DA,Alper CA,Füst G

更新日期：2010-06-01 00:00:00

abstract：:In the present study, we show that the treatment of Epstein-Barr virus (EBV) latently infected Raji cells with TPA/SB caused the cell growth arrest. The Zta-positive cells were predominantly enriched in G0/G1 phase of cell cycle. When Zta expression reached a maximal level, a fraction of Zta expressing cell population...

journal_title：Molecular immunology

authors： Guo Q,Qian L,Guo L,Shi M,Chen C,Lv X,Yu M,Hu M,Jiang G,Guo N

更新日期：2010-05-01 00:00:00

abstract：:Dendritic cells (DC) are comprised of several subsets with distinct functions, differing in their capacity to respond to pathogen products. To gain novel insights into their pathogen specificity, we compared the protein composition of the plasma membrane of CD8+ and CD8- DC, directly isolated from mouse spleens. Diffe...

journal_title：Molecular immunology

authors： Segura E,Kapp E,Gupta N,Wong J,Lim J,Ji H,Heath WR,Simpson R,Villadangos JA

更新日期：2010-05-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) functions in leukocyte trafficking, activation, and the formation of the immunological synapse. ICAM-1 is a member of the immunoglobulin superfamily of adhesion proteins, which share a similar structure of repeating Ig-like domains. Many genes in this family, including ICAM-1...

journal_title：Molecular immunology

authors： Hu X,Barnum SR,Wohler JE,Schoeb TR,Bullard DC

更新日期：2010-05-01 00:00:00

abstract：:The S100A12 gene belongs to the S100 family of genes, which are specific to vertebrates. It is involved in many inflammatory diseases of human and has been considered as a powerful diagnostic gene. In the present study, we identified the porcine S100A12 (pS100A12) gene, provided evidence that pS100A12 is located on ch...

journal_title：Molecular immunology

authors： Chen H,Cheng L,Yang S,Liu X,Liu Y,Tang J,Li X,He Q,Zhao S

更新日期：2010-04-01 00:00:00

abstract：:The two N-linked oligosaccharides in native human C9 were deleted by site-specific mutagenesis. This aglycosyl-C9 did not differ from its native form in hemolytic and bactericidal activity. A new N-glycosylation site (K311N/E313T) was introduced into the turn of a helix-turn-helix [HTH] fold that had been postulated t...

journal_title：Molecular immunology

authors： Rossi V,Wang Y,Esser AF

更新日期：2010-04-01 00:00:00

abstract：:Antibodies (Ab) are bifunctional molecules with two domains, a constant region (C) that confers effector properties and a variable (V) region responsible of antigen (Ag) binding. Historically the C and V regions were considered to be functionally independent, with Ag specificity being solely determined by the V region...

journal_title：Molecular immunology

authors： Janda A,Casadevall A

更新日期：2010-04-01 00:00:00

abstract：:Tehranolide named as new type of a sesquiterpene lactone with an endoperoxide group which purified from Artemisia diffusa and having similar structure to Artemisinin. Tehranolide is hypothesized to possess effects akin to Artemisinin, which is active against cancer cells. In the present research we emphasized on the d...

journal_title：Molecular immunology

authors： Noori S,Taghikhani M,Hassan ZM,Allameha A,Mostafaei A

更新日期：2010-04-01 00:00:00